Further, we compared gene expression profiles between lower and advanced stages of tumours; we identified 200 genes uniquely deregulated in advanced stage cancers, involving pathways such as cell adhesion (VCAN), ECM receptor interaction (COL1A2, COL3A1, ITGA11, and TNN) and pathways in cancer (JUN, and MYC) which may be contributing to increased proliferation, migration and increased angiogenesis in advanced stage of tumours. Here, COL3A1 is linked to neoplasm.