In concordance with the above findings, down-regulated expression of lipid metabolism genes such as LEP, CIDEC, THRSP, PLIN1, GPD1, and FABP4 genes were also reported at the transcript level by various authors in breast54,59–64 and other cancers such as gastric65, hepatocellular66 and keratoacanthomas67. Here, PLIN1 is linked to cancer.