The pathways associated with up-regulated genes include cell cycle, systemic lupus erythematosus, DNA Replication, ECM-receptor interaction, p53 signalling (Supplementary Table S5) while the pathways associated with down-regulated genes include leukocyte transendothelial migration, cell adhesion molecules, adherens junction, complement and coagulation cascade, PPAR signaling, circadian rhythm, focal adhesion, adipocytokine signaling pathway, and tight junction (Supplementary Table S6). This evidence concerns the gene PPARA and systemic lupus erythematosus.