SPP1 and cancer: The topmost interactive up-regulated nodes include, AURKB, CENPA, TOP2A, BUB1, CCNB2, MMP1, and SPP1 genes involved in cancer metastasis, cell cycle, and mitosis; and the down-regulated nodes include CAV1, ACACB, NTRK2, KLF4, and MYH11 genes involved in regulation of Ras-ERK, fatty acid synthesis, MAP kinase and JAK2/STAT3/5, and ATP hydrolysis pathways (Fig. 3).