TOP2A and cancer: Networking analysis was done to identify genes involved in regulation of gene expression in cancer cells, AURKB, CENPA, TOP2A, BUB1, CCNB2, MMP1, and SPP1 were identified as top hub genes from the up-regulated genes; suggesting these genes might be playing key regulatory role in breast carcinogenesis through deregulation of cell cycle and in invasion/metastasis.