Maternal blood Tregs (the percentage of Foxp3+ cells within CD4+ cells) were lower in preeclampsia (p = 0.004, unpaired t-test) and similarly, there were some evidence of cord blood Treg cell frequencies being lower in offspring of preeclamptic versus non-preeclamptic pregnancies (p = 0.09, unpaired t-test) (Fig. 2b). This evidence concerns the gene CD4 and preeclampsia.