To address this point, all of the Disease–Disease (e.g., MS-RESEMBLES_DrD-Amyotrophic Lateral Sclerosis) and Disease–Gene edges (MS-ASSOCIATES_DaG-IL7R and MS-DOWNREGULATES-PALLD) in SPOKE were removed and the PSEVs were recomputed the Disease PSEVs (PSEVΔDD, ΔDG). This evidence concerns the gene IL7R and amyotrophic lateral sclerosis.