These results suggest that p300 can participate in AML1-ETO fusion protein–mediated transcriptional activation of Bcl-2 and that downregulation of c-kit and Bcl-2 may be involved in C646-mediated growth inhibition, cell cycle arrest, and apoptosis in AML1-ETO-positive acute myeloid leukemia cells30. The gene discussed is EP300; the disease is acute myeloid leukemia.