Patients with CTC at T1 less often had a tumor response (2/17, 12%) compared to those without CTC at T1 (19/46, 41%; p = 0.04), but this difference was not significant after adjustment for other factors (PD-L1, PS, number of organs with metastases and histological subtype) (OR = 0.22, p = 0.08). The gene discussed is CD274; the disease is neoplasm.