In patients, the response rate of EGFR mutant tumors to PD-1 or PD-L1 blockade is below 10% and therefore lower than in NSCLC as a whole (RR ~ 20%) potentially due to the lower immunogenicity of the tumors mainly arising in former/never smokers and having a low mutational background [14, 50–52]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.