Finally, we immunostained colon cancer TMAs for PTBP3 and HIF-1α to assess whether PTBP3 regulated HIF1a in human colon cancers, The results showed that PTBP3 expression strongly correlated with HIF-1α IHC scores in colon cancer tissues (Fig. 4f-g). Here, PTBP3 is linked to colonic neoplasm.