Consequently, the long-term use of non-steroidal anti-inflammatory agents in humans, such as indomethacin, sulindac, and PPAR-γ agonist, such as ibuprofen, rosiglitazone, and pioglitazone, has been directly linked with a low risk for developing AD and decreased Aβ deposition in vitro and in vivo [16, 17]. This evidence concerns the gene PPARG and Alzheimer disease.