The presence of somatic mutations in genes including NPM1 (Nucleophosmin 1), CEBPA (CCAAT/enhancer binding protein alpha), c-KIT (tyrosine-protein kinase Kit) and FLT3 (Fms-like tyrosine kinase 3) can also promote myeloid leukemogenesis and influence the prognosis of AML [3]. The gene discussed is NPM1; the disease is acute myeloid leukemia.