The induction fold of IL-23 following exposure to naringin or sericin alone was significantly lower than the untreated hPBMCs from psoriasis patients (5.18, 4.2 and 7.5 fold, respectively) and the effect was markedly seen with naringin/sericin combination (2.3 fold) (Fig. 3d). This evidence concerns the gene IL37 and psoriasis.