No gross ovarian tumours were detected in any cohorts at 6 months of age; however 6/29 (20.7%) of the APC2-deficient cohorts (Apc2+/− and Apc2−/− cohorts on the background of hypomorphic Apc) had developed adult ovarian GCTs at 12–18 months of age as compared to 1/19 (5.26%) of the APC2-proficient (hypomorphic Apc only) cohort developing ovarian GCT at 18 months of age (Table 1). This evidence concerns the gene APC and ovarian neoplasm.