FH and cancer: Iron imbalances between mitochondria and cytosol can have broad pathological consequences in cancer through altered immunometabolism (Li et al., 2018), and the genetic deficiencies of mitochondria-related genes (FH, PINK1) are likely to trigger dysregulation of the mitochondria-cytosol iron balance, which is associated with the Warburg effect and HIF signature in cancer (Li et al., 2018, Tong et al., 2011, Tyrakis et al., 2017).