GMFG and nutritional disorder: More recently, and in accordance with our findings, the knock down of glia maturation factor-γ (GMFG) in macrophages was shown to cause an iron-deficiency response and M2 macrophage polarization associated with reduced mitochondrial respiration chain components, ISCU, and basal oxygen consumption and an increased HIF response (Aerbajinai et al., 2019).