SIRT1 and cardiovascular disorder: Gorenne et al.28 reported that sirtuin 1 expression is reduced inhuman carotid atherosclerotic plaque.28 Breitenstein et al.29 found that peripheral monocyte sirtuin 1 expression waslower in coronary artery disease patients compared to healthy subjects.29 Judging by our results, this studymay arise a debate about the protective functions of circulating sirtuin 1, 3 and 6in cardiovascular disorders.