GLA and Fabry disease: Fabry disease (FD) is an X-linked lysosomal storage disorder caused bymutations in the alpha galactosidase A gene (GLA) that lead to the enzymaticdeficiency of alpha galactosidase (α-Gal A), resulting in theaccumulation of globotriaosylceramide (Gb3) and globotriaosylsphingosine(lyso-Gb3), causing multiple organ dysfunctions.