Among the proteins of interest (NPM1, FLT3, DNMT3A, IDH1, IDH2, KIT, and RAS), non-mutation bearing ligands from NPM1 were the most frequent in both patient tumor samples and cell lines, including ligands close to or corresponding to where hotspot mutations occur (EAIQDLWQW and MTDQEAIQDLWQWR). The gene discussed is NPM1; the disease is neoplasm.