TYMS and hepatocellular carcinoma: In contrast to our findings, Nii et al. found no significant difference in overall survival in patients with high versus low TS mRNA expression in HCC, although there was a “tendency of better prognosis” in the high TS group.[21] Moreover, Okano et al. found no significant difference in overall survival time between patients with high and low levels of TS.[22] There are important differences between those studies and ours.