GPT and Cirrhosis: In the final step of multivariate analysis, rs4646437 genotype CC and cirrhosis were significant, independent factors associated with grade ≥1 ALT elevation [odds ratios, 2.83 and 1.88; 95% confidence intervals, 1.05–7.07 and 1.01–3.50; p = 0.040 and 0.045, respectively] (S4 Table).