Clinical predictors of advanced fibrosis in NASH patients using innovative biomarker combinations such as FIB-C3 (pro-C3, age, BMI, diabetes, and platelet); FIBROSpect test (α2-macroglobulin, hyaluronic acid (HA), tissue inhibitor of metalloproteinase-1 (TIMP-1)); and HA+CK18+TIMP-1 yielded AUROC of 0.86, 0.87, 0.90 respectively (reviewed in [49]). The gene discussed is KRT18; the disease is metabolic dysfunction-associated steatohepatitis.