For others, IgE plasma levels are elevated: DOCK8 deficiency, autosomal dominant hyper-IgE syndrome (AD-HIES) Job’s syndrome, Comel-Netherton syndrome, PGM3 deficiency, IPEX (immune dysregulation, polyendocrinopathy, enteropathy X-linked) and Tyk2 deficiency. Here, IGHE is linked to Autosomal dominant hyper-IgE syndrome.