For example, interleukin 1 beta (IL1B), a Th1 promoting cytokine is found to be increased in CD4+ T cells in allergic patients (Figure 3C, from GSE70760), but in the nasal epithelium, the gene is not upregulated in patients with severe case of allergic rhinitis (`uncontrol asthma’) compared against healthy control (Figure 3D, from GSE19190). This evidence concerns the gene CD4 and allergic rhinitis.