From a pathophysiological standpoint, PNI appears to be mediated by the expression of neural cell adhesion molecules on the surface of OCSCC tumor cells (which facilitate their spread through the perineural tissue).7 A better understanding of the molecular underpinnings of PNI in OCSCC may facilitate the development of more effective therapeutic strategies in the next future.21, 31. Here, CHL1 is linked to neoplasm.