Further, LP‐CQPC01‐FSM increased the mRNA and protein expression of Cu/Zn‐SOD, Mn‐SOD, CAT, c‐Kit, SCF, and GDNF and reduced the expression of TRPV1 and NOS relative to those of the mice with untreated constipation. The gene discussed is GDNF; the disease is constipation disorder.