Myc has been implicated in the transcriptional repression of miR-15a/16-1 expression in B-Cell Lymphoma [24, 39], Ewing’s sarcoma [26] and colorectal carcinoma [25], and was also shown to interact with HDAC3 to indirectly repress expression of miR-15a/16-1 in Mantle Cell Lymphoma (MCL) [39]. This evidence concerns the gene MYC and Ewing sarcoma.