Although Myc was shown to bind the promoters of both genes, it is likely that Myc-induced miRNA suppression also plays a role as miR-15a, 15b and 16 directly regulate PD-L1 expression [51, 52], and furthermore, Myc expression correlates with PD-L1 expression in lung cancer [53]. The gene discussed is MYC; the disease is lung carcinoma.