Although Myc is regularly involved in the activation of gene expression, and promotes expression of the oncogenic miR-17-92 cluster in B-cell lymphoma, lung cancer [41] and chronic myeloid leukemia (CML) [42], it has become increasingly clear that Myc directly represses multiple miRNAs in cancer [26, 40, 41, 43, 44]. The gene discussed is MYC; the disease is cancer.