Interestingly, compared with the DTC-specific interactome (3 major clusters include BRAF, NRAS, and P53), the aggressive thyroid cancers-mediated interactome reveals very complex (>13 major clusters by vital protein molecules such as NRAS, P53, AKT3, BRAF, TERT, PTEN, PIK3CA, EGFR, RAC1, CTNNB1, EBP300, CREBBP, MAPK1, etc.)and multi-node interactions in each protein molecule. The gene discussed is TP53; the disease is thyroid cancer.