However, only one case had concomitant PIK3CA and PTEN mutation suggesting a weaker oncogenic potential of PIK3CA and requirement of a loss of tumor suppressor-like PTEN. Recent deep sequencing of DTCs (PTCs) identified PIK3CA and PTEN mutations in samples with distant metastasis [32] suggesting that the DTCs with these mutations are likely to progress into aggressive poorly differentiated thyroid cancer (PDTCs). Here, PIK3CA is linked to poorly differentiated thyroid gland carcinoma.