Another approach still in its infancy uses CAFs and CAF-derived factors as ecological traps, designed to mimic the normal niche to attract disseminated cancer cells that are subsequently killed via methods, such as TRAIL-induced apoptosis and trap-targeted stereotactic radiation.107 However, this method involves surgical implantation, creating a wound site that in itself was observed to activate tissue-resident fibroblasts and attract more cancer cells.107 One group was able to encapsulate live CAFs in microparticles that could then be intraperitoneally injected, without wounding. Here, TNFSF10 is linked to cancer.