Reduced fibroblast content and activity, impaired collective CAF-tumour cell invasion and delayed melanoma growth in vivo resulted.85 Secondly, targeting the RNA editor, Adenosine Deaminase family acting on RNA (ADAR1), appears warranted in CRC; ADAR1 is overexpressed in human CRC and leads to elevated antizyme inhibitor 1 (AZIN1) RNA editing levels, which is correlated with increased CAF marker expression and aggressive tumours.86 This evidence concerns the gene ADA and colorectal carcinoma.