TGFB1 and neoplasm: Interestingly, CAFs were enriched in TGF-β signalling and fibrosis and produced nitric oxide to suppress T-cell proliferation; CAPs were not immunosuppressive.117 Moreover, Biffi et al.118 demonstrated that myofibroblastic CAFs (myCAFs) were found adjacent to PDAC tumours, while inflammatory CAFs (iCAFs) were preferentially localised in the dense PDAC stroma.