One study demonstrated that they define completely different CAF subsets, at least in CRC, with α-SMA associating with other activated fibroblast markers such as transgelin (TAGLN) and platelet-derived growth factor subunit A (PDGFA), whilst FAP associated with other markers, including DCN and COL1A2.10 It is worth noting that this was the first comprehensive study that attempted to define human CAF subsets, using single-cell sequencing. Here, TAGLN is linked to colorectal carcinoma.