ACTA1 and neoplasm: PDAC is notorious for its large fibrotic tumour response, with the majority of tumour volume being composed of α-SMA+ fibroblasts.8 Depleting these fibroblasts was hypothesised to reduce PDAC aggression, but clinical studies relying on this strategy revealed accelerated disease progression.59 Upon further investigation in mice, it was confirmed that deletion of α-SMA+ fibroblasts induced invasive tumours that showed enhanced EMT and increased numbers of CSCs, and resulted in reduced survival.