Interest surrounding serum amyloid A (Saa3) expression in mouse Pdgfrα+ CAFs has also recently come into light, as Pdgfrα+Saa3+ CAFs were shown to stimulate PDAC growth in an orthotopic mouse model while Pdgfrα+Saa3− CAFs inhibited growth.56 Inhibiting Saa3 could therefore result in an abundance of anti-tumour CAFs, but the initial findings of this study await further validation as to their suitability as a therapeutic target for PDAC. Here, PDGFRA is linked to neoplasm.