Immortalized hSCs express SC-characteristic proteins (e.g. S100B), transcription factors (e.g. Slug, TWIST), cell surface receptors (e.g. p75NTR), chemokines (e.g. CCL2) and neurotrophic factors (e.g. NGF, BDNF, NT-3) and can myelinate axons in vitro36, but have not been evaluated for susceptibility or response to virus infection. Here, S100B is linked to viral infectious disease.