We observed reduced, albeit not statistically significant, serum magnesium levels among the 6 NPC cases from our families with NIPAL1 variants compared to 7 unaffected individuals from these same families (1.9 mg/dL vs. 2.1 mg/dL; p-value 0.11) (Fig. 1). Here, NIPAL1 is linked to nasopharyngeal carcinoma.