Dlg1 is involved in the establishment of polarity in fruit flies (Humbert et al., 2008) and required for adherens junction formation in C. elegans (Firestein and Rongo, 2001), and while its role in mammalian epithelial polarity is less clear, if loss of Dlg1 globally affected the polarity of the cyst this might indirectly affect spindle orientation. The gene discussed is DLG1; the disease is cyst.