The hepatitis C virus, which is linked to the development of liver cancer, causes a mislocalisation of Dlg1 away from the cell cortex (Awad et al., 2013), which leads to multilumen formation in MDCKII cysts (Awad et al., 2013); our results indicate this is likely to involve misorientation of the mitotic spindle. This evidence concerns the gene DLG1 and liver cancer.