In accordance with our statistically significant findings of the allele model, the minor allele of rs10426502, and rs1060555 in TNFAIP8L1 played roles in reducing the risk of cervical cancer in Uygur women over 43 years old (rs10426502: OR = 0.44, 95% CI: 0.22–0.88, P=0.017; rs1060555: OR = 0.72, 95% CI: 0.53–0.97, P=0.033). The gene discussed is TIPE1; the disease is cervical cancer.