In accordance with our statistically significant findings of the allele model, the minor allele of rs10426502, and rs1060555 in TNFAIP8L1 played roles in reducing the risk of cervical cancer in Uygur women over 43 years old (rs10426502: OR = 0.44, 95% CI: 0.22–0.88, P=0.017; rs1060555: OR = 0.72, 95% CI: 0.53–0.97, P=0.033). This evidence concerns the gene TIPE1 and cervical carcinoma.