JQ1, OTX, and I-BET at lower concentration (0.05 or 1μM) had a minimum inhibitory effect on proliferation of DHL and THL cells, although at higher concentrations such as 2.5 μM or 5 μM all of the three inhibitors significantly abrogated the proliferation of DHL/THL DLBCL cells and the inhibitory effect was similar to that observed in wild-type MYC overexpressing DLBCL cells. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.