The relevance of cellular pathways such as STAT3 with 15-Lox-regulated cancer cell proliferation as well as the activation of intracellular signaling pathways such as Ras, MAP kinase and NF-κB with 15-Lox products have been demonstrated previously [18, 38] and enlighten the correlation of 15-Lox-1 with cell proliferation since our data demonstrated the higher level of 15-Lox-1 in tumors with higher proliferation rate (macroadenomas). The gene discussed is STAT3; the disease is cancer.