Due to the role of 15-Lox pathway in the pathogenesis of several types of cancers and its direct contribution in regulating cancer cell proliferation/apoptosis, the results of the current study can provide insights in to the possible role of 15-Lox enzyme in the pathogenesis of pituitary adenoma however considering the involvement of all lipoxygenase (5-Lox, 12-Lox and 8-Lox) isoforms and their subsequent products as well as the levels of various PGs, LTs and TXs in pituitary adenoma samples is perquisite to clarify the balance status of eicosanoid cascade in pituitary adenoma pathogenesis .. The gene discussed is ALOX15; the disease is pituitary gland adenoma.