The uncontrolled proliferation of anterior pituitary gland resulted in several types of tumors with diverse pathological symptoms including acromegaly (growth hormone over production) prolactinoma (prolactin over production) and cushing’s disease (cortisol over production) as the most prevalent functional pituitary adenoma (FPA) also the non-functional pituitary adenomas (NFPA) which lacks hormone excess [25]. The gene discussed is GH1; the disease is pituitary gland adenoma.