Although none of the ARKs (unlike AMPK) are known to inhibit cell growth and proliferation, knockdown of LKB1 using RNAi was reported to enhance expression of SNAIL, a protein that promotes the epithelial-to-mesenchymal transition, and hence metastasis of tumour cells, by reducing the phosphorylation of DIXDC1 by two of the ARKs, MARK1 and MARK4 [160]. This evidence concerns the gene PRKAA2 and neoplasm.