PRKAA1 and lymphoma: For example, in the Eμ-Myc model [185], loss of AMPK-α1 would have occurred during embryogenesis whereas, although over-expression of Myc in pre-B cells has certainly occurred by 35–50 days of age [186], lymphomas do not start to arise until 50 days and their median onset is ≈80 days [187].