PRKAA1 and B-cell non-Hodgkin lymphoma: A drawback with this B-cell lymphoma model was that Prkaa1 was knocked out globally [163], so it was not possible to conclude that the effect was due to a cell-autonomous loss of AMPK-α1 in the B-cell progenitors themselves, rather than an indirect effect of loss of AMPK-α1 in some other cell type.