The further optimized and synthesized dissymmetric N-phenylsulphonyl-BAPs 23 and 76 can prevent the nuclear translocation of NF-κB induced by inflammatory cytokines (lipopolysaccharide (LPS), TNF-α) and exhibit both anti-inflammation and anti-cancer capability in hepatic carcinoma cell lines13,.14 Here, NFKB1 is linked to cancer.