Moreover, the impact of ART on the half-life of anti-Env Ab titers and ADCC functional antibodies is poorly defined.29,30 Since Ab titers rebound more rapidly during ART interruption compared with initial infection,28 and HIV+ individuals on ART respond well to influenza A vaccination,31 vaccination to boost antibodies mediating ADCC could form part of an eradication strategy in patients on suppressive ART. This evidence concerns the gene ERVW-1 and infection.