Despite harboring mutations in two genes with different functions, PLOD1-kEDS and FKBP14-kEDS patients share a common clinical phenotype with major criteria consisting of congenital muscle hypotonia, congenital or early onset kyphoscoliosis, and generalized joint hypermobility; shared minor criteria include skin hyperextensibility, rupture, or aneurysm of medium-sized arteries, easy bruising of skin, and osteopenia or osteoporosis. This evidence concerns the gene FKBP14 and Osteopenia.