We sought to identify DEGs in PLOD1-kEDS and FKBP14-kEDS that are involved in modulating the vasculature, since rupture or aneurysm of medium-sized arteries have been described in both PLOD1-kEDS [12,37] and FKBP14-kEDS [3,38,39] and serves as a minor criteria in the diagnosis of kEDS [1]. Here, PLOD1 is linked to aneurysm.