TRPC3 and posterior cortical atrophy: Among them, three ‘prostate-associated’ channels (TRPA1, TRPV2, and TRPC3) were overexpressed during PCa angiogenesis and showed proangiogenic activity by exerting effects on the principal EC properties during angiogenesis, particularly EC proliferation, to support sprout formation, directed motility guiding, sprout elongation and in vitro and in vivo morphogenesis regulation.