Immunohistochemical staining of the brain from wild-type and an AD-like mouse model, APP/PS1dE9 transgenic mice, with anti-Aβ, anti-TSPO, and anti-Iba-1 antibodies (marker for microglia/macrophage), showed that plaque-associated Iba-1 was observed in cortex, hippocampus, cerebellum striatum, and thalamus, while plaque-associated TSPO was seen at all sites other than the thalamus [128]. Here, TSPO is linked to Alzheimer disease.