NIR dye labeled Nbs were documented for tumor imaging and tumor surgery imaging, for example, by using an anti-HER2 nanobody labeled with the IRDye800CW for ovarian cancer [13,14], an epidermal growth factor receptor (EGFR)-targeting nanobody for head and neck cancer [15], and ARTC2-specific nanobody for lymphoma cells [16,17]. This evidence concerns the gene ERBB2 and neoplasm.