TCF4 and glioblastoma: We also investigated β-catenin/TCF4-mediated NRF3 regulation in other human cancer cell lines: DLD-1 (colorectal adenocarcinoma), H1299 (non-small cell lung carcinoma), A172 (glioblastoma) and HeLa (cervical epithelioid carcinoma) (Figure 3A).