As PI3K and mTOR signaling are crucial regulators of radiation resistance and self-renewal in many carcinomas, including cervical carcinoma (Kim et al., 2010), head and neck squamous cell carcinoma (Leiker et al., 2015), and breast carcinoma (Steelman et al., 2011), it is important to note that mEAK-7 is also a strong effector of these processes. Here, MEAK7 is linked to head and neck squamous cell carcinoma.