Notably, when STRING network analysis (Szklarczyk et al., 2017) was used to investigate functional interactions, this revealed a DDR cluster that included BRCA1 and BRCA2, as well as their interacting tumour suppressor partners PALB2 and BAP1, two cancer-associated DDR genes not previously indicated as G4 ligand sensitisers. This evidence concerns the gene PALB2 and cancer.