Role of NK cells and other innate lymphoid cells in cancer has been recently reviewed.27 Various mechanisms could be involved in the role of NK cells in CML such as ligands shedding in microenvironment, downregulation of activating receptors such as NKG2D and NCRs, clonal expansion of MDSC.28 Moreover, several studies support that TKI exert an immunomodulatory off‐target effect on immune system,29 with a direct effect on NK cell number, an increase of previously described downregulated receptors, and an inhibition of TReg immunosuppressive function and MDSC expansion. The gene discussed is KLRK1; the disease is cancer.