The miR‐351 inhibitor + siRNA‐FLOT2 group showed aggravated morphological deformation, and increased intracellular and intercellular PAS staining with obviously increased glycogen granules and nucleus vacuoles in comparison to the siRNA‐FLOT2 group.31 All above, it was cleared that the pathological changes of liver cells could be alleviated by overexpressing miR‐351 and silencing of FLOT2 in GDM mice. The gene discussed is FLOT2; the disease is gestational diabetes.