Moreover, it was demonstrated that the alteration of the PI3K/AKT pathway could influence GDM,29 and other studies revealed that FLOT2 could regulate the PI3K/AKT pathway.14, 30 With this respect, we speculated that the differential expression of FLOT2 may regulate the PI3K/AKT pathway in GDM. The gene discussed is AKT1; the disease is gestational diabetes.