It would be interesting to investigate whether overexpression of SHIP‐1 in MSCs or application of a small molecule agonist to enhance SHIP‐1 activity (Viernes, Choi, Kerr, & Chisholm, 2014) would delay the chondrocyte hypertrophic process in an autologous chondrocyte implantation osteoarthritis animal model. The gene discussed is INPP5D; the disease is osteoarthritis.