PLPP3 and coronary artery disorder: We illustrated our strategy by characterizing a TNFα-responsive regulatory element that controls the expression of the novel CAD candidate gene AIDA. Encouragingly, a recent report identified another CAD-associated regulatory variant of PLPP3 that resides within a vascular endothelial enhancer activated by shear stress [34], suggesting that many CAD- and BP-associated variants may influence vascular endothelial phenotypes.