The early asymptomatic phase of type 1 diabetes is detected by the presence of autoantibodies against pancreatic β cell antigens such as insulin, glutamic acid decarboxylase (GAD), insulinoma-associated protein 2 (IA-2) and zinc transporter 8 (ZnT8) [1, 2]. The gene discussed is INS; the disease is type 1 diabetes mellitus.