CDH1 and neoplasm: The phosphorylation and ubiquitination of Y755-757F E-cadherin induced the EMT phenotype in A549 cells, like E-cad WT (Fig. 6e, f, and g), whereas Y797F E-cadherin impaired the phosphorylation of E-cadherin and failed to restore tumor cell aggressiveness via sequestering β-catenin, leading to abolished changes in EMT biomarkers and morphology (Fig. 6e, f, and g).