Hsc70 is not only the essential chaperone in the CMA translocation system that allows substrate protein entry into the lysosomal lumen (Cuervo & Wong, 2014) but also plays a critical role in neuronal death associated with neurodegenerative diseases due to its significant downregulation both in PD and AD (Alzheimer's disease) (Alvarez‐Erviti et al., 2010; Sala et al., 2014; Silva et al., 2014). Here, HSPA8 is linked to Alzheimer disease.