CCND1, also named as cyclin D1, belongs to D cyclin family and drives the cell cycle progression of G1 to S phase.14, 15 The CCND1 overexpression or CCND1 downstream pathway  aberrant activation could directly promote neoplastic growth. Therefore CCND1 overexpression could be detected in different human tumors such as hepatocellular carcinoma, breast cancer and glioma.16, 17, 18. Here, CCND1 is linked to hepatocellular carcinoma.