Oral administration of BMS309403 attenuated renal ER stress in AKI and the related ERS protein expression of GRP78, CHOP, p‐PERK and ATF4.38 In contrast to cisplatin‐induced AKI, pharmacological and genetic inhibition of FABP4 also alleviated AKI by the modulation of apoptosis via the inactivation of ER stress in the tubular epithelial cells. This evidence concerns the gene DDIT3 and acute kidney injury.