Fatty acid‐binding protein 4 (FABP4), as a lipid‐binding chaperone, is highly expressed in adipocytes and macrophages.16, 17 The mitigation of ER stress and apoptosis is protective effects against atherosclerosis because FABP4 was an obligatory intermediate for macrophage ER stress response to lipids.18, 19 Chemical or genetic inhibition of FABP4 could improve atherosclerosis and type 2 diabetes mellitus, and targeting FABP4 offered therapeutic for inflammation and metabolic diseases. Here, FABP4 is linked to atherosclerosis.