Apoptotic pathways in the tubular epithelium could be induced by caspase cascade activation, mitochondrial injury and ER stress.31 Apoptosis also promoted the loss of renal epithelial cells that characterized AKI.5 Accumulating evidence demonstrated that the activation of caspase 3 was predominant which responsible for renal tubular cell apoptosis in cisplatin‐induced AKI. The gene discussed is CASP3; the disease is acute kidney injury.