CD274 and cancer: For non-small cell lung cancer, durvalumab, a PD-L1 inhibitor, has been approved based on the results of the PACIFIC study, a randomized, double-blind, placebo-controlled, multicenter phase III study of durvalumab administered sequentially in patients with unresectable locally advanced cancer (stage III) who did not show disease progression after curative concurrent chemoradiotherapy (CRT) using platinum drugs [66].